Not normally our ballpark. There are plenty of PCB manufacturers wanting large runs and offering very competitive prices to get them. Just try and make sure you don't deal with one that is verging on insolvency. Most companies take out credit checks on potential customers, few think to do the same for potential suppliers.
We are happy for customers to put their really large requirements elsewhere whilst staying with us for their smaller runs and urgent work, but we are always pleased to quote for even the largest runs.